This study was carried out to investigate the antibacterial and antifungal potential of Nelsonia canescens leaf. Methanol extract of Nelsonia canescens leaf was evaluated for antimicrobial activity against medically important bacterial and fungal strains, extract (5, 25, 50, 100, 250 μg/ml dilutions) using agar disc diffusion method. against two gram positive S. aureus, S. pyogenes, two gram negative- E. coli, P. aeruginosa human pathogenic bacteria and three fungal strains- A.niger, A. clavatus, C. albicans respectively. A zone of inhibition of extract was compared with that of different standards like Ampicilline, Ciprofloxacin, Norfloxacin and Chloramphenicol for antibacterial activity and Nystain and Greseofulvin for antifungal activity. The extract showed antibacterial and antifungal activities comparable with that of standard against the organisms tested. The results showed remarkable inhibition of the bacterial growth against the tested organisms.
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